Empirical antibacterial treatment of infection with Chlamydophila pneumoniae in Multiple Sclerosis

Empirical antibacterial treatment of

• antibodies to C. pneumoniae in the cerebrospinal fluid of patients with the disease [(1.) Yao, S., Stratton, C.W., Mitchell, W.M., Sriram, S. (2001). CSF oligoclonal bands in multiple sclerosis represent antibodies against Chlamydophila. Neurology 56, 1168-76. (2.) Fainardi, E., Castellazzi, M., Casetta, I. et al. (2004). Intrathecal production of Chlamydia pneumoniaespecific high-affinity an...

Chlamydophila pneumoniae infection of the central nervous system in patients with multiple sclerosis.

BACKGROUND Chlamydophila pneumoniae has been postulated as an aetiological agent in the pathophysiology of multiple sclerosis. Previous studies show conflicting results. OBJECTIVE To investigate patients with multiple sclerosis and other neurological diseases for evidence of past or present infection with C pneumoniae. METHODS 19 patients with multiple sclerosis and 29 with other neurologic...

Chlamydophila pneumoniae Infection and Its Role in Neurological Disorders

Chlamydophila pneumoniae is an intracellular pathogen responsible for a number of different acute and chronic infections. The recent deepening of knowledge on the biology and the use of increasingly more sensitive and specific molecular techniques has allowed demonstration of C. pneumoniae in a large number of persons suffering from different diseases including cardiovascular (atherosclerosis a...

Analysis of intrathecal antibody production against Chlamydia pneumoniae in multiple sclerosis patients

Role of Chlamydophila pneumoniae in the Pathogenesis of Chronic Cerebrospinal Venous Insuffiency in Patients with Multiple Sclerosis

Although the aetiology of Multiple Sclerosis (MS) is unknown, genetic and environmental factors including infectious agents may play a role in the development of this disease. Recent studies have demonstrated chronic cerebrospinal venous insufficiency (CCSVI) as a potential factor in the pathogenesis of clinically defined MS but current evidence does not support a substantial role of CCSVI in t...